Hello puddlepie23,
There is no correlation between embryo grading and gender. What you read might be very small studies without good research design.
There has been publication claiming that if a blastocyst has only been biopsied/PGT once but freeze-thawed twice, there is no negative impact on its implantation potential and success rate. This scenario is quite common because many patients chose not to do PGT when they had the egg retrieval, but changed their mind after one or more unsuccessful embryo transfer or miscarriages. On the other hand, when a blastocyst has been biopsied twice for PGT and therefore also been freeze-thawed twice, there is some negative impact, although the second biopsy/freeze-thaw might not reduce the implantation potential and success to zero.
Trying to explain this logically, we know that a blastocyst biopsy involves taking a few cells from the trophectoderm layer of the embryo for PGT testing, and also we know lower grade embryos, e.g. 5BC, has fewer cells in the trophectoderm compared to a good quality embryo. It will be reasonable to argue that in a low-grade embryo, by taking away a fixed amount of cells, the embryo may not recover as good as a high-grade embryo. Sometimes, how many cells the embryologist may have taken from the embryo, whether biopsied once or twice, can also affect the embryo's potential. My point is, there are always risks in every step, big or small. Depending on what the situation is, we may decide differently. The best choice can usually be made when talking to your embryologists (when embryo is the subject of concern). Very often they also have a photo of that particular embryo, and the explanation may become easier.
Thank you for the detailed explanation.
How many embryos should one expect to lose in PGT testing? I have read about 40%. We have 3 which are grade 3BC and 4CC (they seem low grade to me?). We are only intending to transfer in about 2 years time so may consider doing another round of IVF now to have more options.
Dear puddlepie23,
I will not call it a "loss" because there is no point to transfer an embryo that cannot get you a healthy baby. Some of those embryos, if untested and therefore unknown, can give you a miscarriage, which to me is worse than not getting pregnant in the first place. Do not even think in retrospect the "what if's", e.g. what if I did not do PGT and blind transfer, what if I did not culture it to blastocyst, what if... etc etc. If you do not want to believe in an aneuploid (abnormal embryo) result, you should not do PGT.
How many "usable" embryos after PGT depends on age and the reason(s) that lead you to choose PGT. Your quoted 40% loss is a little on the optimistic side. As long as your embryos can be biopsied and results available, the grading of the embryo is not very important. If you will not be transferring the euploid(s) real soon, doing another round of IVF is reasonable, in the hope to accumulating a few euploids for later use.
Hi maylee630,
I still recommend NIPT and NT screening, because these 2 tests are standard care and will be performed in natural pregnancies. It is good to have reassurance during the 9 months of pregnancy.
發表於 
返回列表
